Journal of heterocyclic chemistry

A new and improved synthesis of 6??aryl??1, 2, 4??triazolo [4, 3??b] pyridazines

DF Lieberman, JD Albright

Index: Lieberman, Daniel F.; Albright, J. Donald Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 827 - 830

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Citation Number: 11

Abstract

Abstract A new and improved synthesis of 6-aryl-1, 2, 4-triazolo [4, 3-b] pyridazines is described. This methodology provides the title compounds under mild conditions and in high yields. The first step comprises the condensation of an aryl methyl ketone with a 4-amino-1, 2, 4-triazole in toluene heated at reflux. The second step involves the condensation of that imine and t-butoxybis (dimethylamino) methane in tetrahydrofuran at ambient temperature ...