Abstract The discovery of the pronounced anti-rickettsial activity of p- sulphonamidobenzamidine on experimental typhus infections in mice has led to a search for compounds of enhanced therapeutic action. A large number of compounds have been prepared in development of the sulphonamido-amidine structure, but anti-rickettsial activity has been found to be confined to about a dozen substances intimately related to p- ...
![N-Hydroxybenzo[d][1,3]dioxole-5-carboximidamide Structure](https://image.chemsrc.com/caspic/337/4720-72-3.png)
