Advanced Synthesis & Catalysis

Highly Active Palladium Catalyst for the Sonogashira Coupling Reaction of Unreactive Aryl Chlorides

DH Lee, YJ Kwon, MJ Jin

Index: Lee, Dong-Hwan; Kwon, Young-Jun; Jin, Myung-Jong Advanced Synthesis and Catalysis, 2011 , vol. 353, # 17 p. 3090 - 3094

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Citation Number: 14

Abstract

Abstract This communication reports on the β-diketiminatophosphane palladium-catalyzed copper-free Sonogashira coupling of aryl chlorides with alkynes. A catalyst loading of 0.5 mol% is sufficient to achieve high performance under relatively mild reaction conditions. Furthermore, dialkynylbenzenes are efficiently prepared by one-pot double Sonogashira couplings of aryl dichlorides.

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