e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Substituted Benzopyranopyridine and Pyrimidine Ring Syntheses by the Ternary Condensation of Ethyl Cyanoacetate, Salicylaldehyde, and Certain Aldehydes in the …
A Sakurai, H Midorikawa, Y Hashimoto
Index: Sakurai,A. et al. Bulletin of the Chemical Society of Japan, 1971 , vol. 44, p. 1677 - 1682
Various 1-substituted benzopyranopyridines were readily prepared by the condensation of ethyl cyanoacetate and salicylaldehyde (or 3-methoxysalicylaldehyde) with aliphatic aldehydes (propion, n-butyl, n-and isovaleraldehyde) in the presence of ammonium acetate. On the other hand, condensation with aromatic aldehydes such as benzaldehyde and o-, m-, or p-substituted benzaldehydes gave 2-aryl-benzopyranopyrimidines.
