Synthesis and Evaluation of Coumarin. ALPHA.-Methylene-. GAMMA.-butyrolactones: A New Class of Platelet Aggregation Inhibitors.

…, TC WANG, SC LIANG, CM TENG, CC TZENG

Index: Chen, Yeh-Long; Wang, Tai-Chi; Liang, Shiu-Chuan; Teng, Che-Ming; Tzeng, Cherng-Chyi Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 8 p. 1591 - 1595

Full Text: HTML

Citation Number: 24

Abstract

In a search for new inhibitors of platelet aggregation, certain coumarin-bearing α-methylene- γ-butyrolactones were synthesized and evaluated for inhibitory activity against thrombin (Thr)-, arachidonic acid (AA)-, collagen (Col)-, and platelet-activating factor (PAF)-induced aggregation in washed rabbit platelets. These compounds were efficiently synthesized from commercially available 7-hydroxycoumarin or its derivative. Among them, 7-[(2, 3, 4, 5- ...