Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models

E Nuti, F Casalini, S Santamaria, M Fabbi…

Index: Nuti, Elisa; Casalini, Francesca; Avramova, Stanislava I.; Santamaria, Salvatore; Fabbi, Marina; Ferrini, Silvano; Marinelli, Luciana; La Pietra, Valeria; Limongelli, Vittorio; Novellino, Ettore; Cercignani, Giovanni; Orlandini, Elisabetta; Nencetti, Susanna; Rossello, Armando Journal of Medicinal Chemistry, 2010 , vol. 53, # 6 p. 2622 - 2635

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Citation Number: 7

Abstract

Activated leukocyte cell adhesion molecule (ALCAM) is expressed at the surface of epithelial ovarian cancer (EOC) cells and is released in a soluble form (sALCAM) by ADAM- 17-mediated shedding. This process is relevant to EOC cell motility and invasiveness, which is reduced by inhibitors of ADAM-17. In addition, ADAM-17 plays a key role in EGFR signaling and thus may represent a useful target in anticancer therapy. Herein we report ...