Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents

NR Penthala, TR Yerramreddy, PA Crooks

Index: Penthala, Narsimha Reddy; Yerramreddy, Thirupathi Reddy; Crooks, Peter A. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1411 - 1413

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Citation Number: 12

Abstract

A series of novel substituted (Z)-5-((1-benzyl-1H-indol-3-yl) methylene) imidazolidin-2, 4- diones (3a–f) and (Z)-5-((1-benzyl-1H-indol-3-yl) methylene)-2-iminothiazolidin-4-ones (3g– o) have been synthesized utilizing microwave irradiation. These analogs were evaluated for in vitro cytotoxicity against a panel of 60 human tumor cell lines. Compound 3i exhibits potent growth inhibition against melanoma UACC-257 (GI50= 13.3 nM) and OVCAR-8 ...

New Nucleotide-Competitive Non-Nucleoside Inhibitors of Term...

[Costi, Roberta; Cuzzucoli Crucitti, Giuliana; Pescatori, Luca; Messore, Antonella; Scipione, Luigi; Tortorella, Silvano; Amoroso, Alessandra; Crespan, Emmanuele; Campiglia, Pietro; Maresca, Bruno; Porta, Amalia; Granata, Ilaria; Novellino, Ettore; Gouge, Jeroime; Delarue, Marc; Maga, Giovanni; Di Santo, Roberto Journal of Medicinal Chemistry, 2013 , vol. 56, # 18 p. 7431 - 7441]

Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl...

[Zhu, Wufu; Liu, Yajing; Zhai, Xin; Wang, Xiao; Zhu, Yan; Wu, Di; Zhou, Hongyu; Gong, Ping; Zhao, Yanfang European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 162 - 175]