Expeditious synthesis and biological evaluation of novel 2, N 6-disubstituted 1, 2-dihydro-1, 3, 5-triazine-4, 6-diamines as potential antimalarials

D Gravestock, AL Rousseau, ACU Lourens…

Index: Gravestock, David; Rousseau, Amanda L.; Lourens, Anna C.U.; Moleele, Simon S.; Van Zyl, Robyn L.; Steenkamp, Paul A. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2022 - 2030

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Citation Number: 20

Abstract

A small set of novel 2, N6-disubstituted 1, 2-dihydro-1, 3, 5-triazine-4, 6-diamines was prepared possessing a flexible tether between the exocyclic nitrogen bonded to C-6 of the 1, 2-dihydro-1, 3, 5-triazine-4, 6-diamine heterocycle and the distal aryl ring. Three zones were varied in this series of compounds, namely the nature of the substituent (s) on C-2; the nature of the substituent (s) on the distal aryl ring; as well as the nature and length of the ...