Synthesis and Biological Evaluation of Heteroaryldiamides and Heteroaryldiamines as Cytotoxic Agents, Apoptosis Inducers and Caspase??3 Activators

M Echeverría, B Mendívil, L Cordeu…

Index: Archiv der Pharmazie, , vol. 339, # 4 p. 182 - 192

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Citation Number: 9

Abstract

... 2006, 339, 182 – 192 refluxing methanol with sodium cyanide as the catalyst (Scheme 2). ... www.archpharm.com Table 1. Experimental data for new compounds 1–6. ... 1a Pyridyl 3 – (CH2)4 – 52 202-3 EtOH C16H18N4O2 1b Pyridyl 3 1,4-piperazine 38 198-9 EtOH C16H16N4O2 ...