Synthesis and monoamine transporter affinity of front bridged tricyclic 3β-(4′-halo or 4′-methyl) phenyltropanes bearing methylene or carbomethoxymethylene on …

…, N Jarkas, MJ Owens, CD Kilts, CB Nemeroff…

Index: Zeng, Fanxing; Jarkas, Nachwa; Owens, Michael J.; Kilts, Clinton D.; Nemeroff, Charles B.; Goodman, Mark M. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4661 - 4663

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Citation Number: 4

Abstract

A series of front bridged tricyclic 3β-(4′-halo or 4′-methyl) phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2β-position was synthesized, and their binding affinities were determined in cells transfected to express human norepinephrine transporter (NET), serotonin transporter (SERT), and dopamine transporter (DAT) via competition binding assays. All compounds studied in this series exhibit a ...