Oxidative coupling of methyl 6-hydroxyindole-2-carboxylate with primary amines. Preparation of 2-substituted methyl pyrrolo [2, 3-e] benzoxazole-5-carboxylates

…, LR Cerbone, D Yohannes

Index: Boger, Dale L.; Cerbone, Louis R.; Yohannes, Daniel Journal of Organic Chemistry, 1988 , vol. 53, # 21 p. 5163 - 5166

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Citation Number: 16

Abstract

In the conduct of synthetic efforts on the antitumor antibiotic (+)-CC-1065 (1) and functionally related agents we have noted the instability of PDE-I (2), PDE-I1 (31, PDE-I dimer (4), and structurally related intermediates to mild, oxidative conditions. 2 We have suggested that the oxidative lability of the central and right-hand subunits of (+)-CC-1065 and structurally related agents may be due (1)(a) National Institutes of Health research career ...