Regiocontrolled Synthesis of 1, 2??Diaryl??1H??imidazoles by Palladium??and Copper??Mediated Direct Coupling of 1??Aryl??1H??imidazoles with Aryl Halides under …

F Bellina, S Cauteruccio, L Mannina…

Index: Bellina, Fabio; Cauteruccio, Silvia; Mannina, Luisa; Rossi, Renzo; Viel, Stephane European Journal of Organic Chemistry, 2006 , # 3 p. 693 - 703

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Citation Number: 55

Abstract

Abstract A large variety of 1, 2-diaryl-1H-imidazoles, including a selective COX-2 inhibitor, have been regioselectively synthesised in moderate to high yields by direct coupling of 1- aryl-1H-imidazoles with aryl iodides or bromides in DMF in the presence of CsF and catalytic amounts of Pd (OAc) 2 under ligandless conditions. A possible mechanism for this new highly regioselective C-2 arylation reaction, involving the formation of an organocopper (I) ...