Synthesis and antinociceptive activity of capsinoid derivatives

GJ He, XL Ye, X Mou, Z Chen, XG Li

Index: He; Ye; Mou; Chen; Li European Journal of Medicinal Chemistry, 2009 , vol. 44, # 8 p. 3345 - 3349

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Citation Number: 13

Abstract

According to the data of structural identification, six capsinoids or their derivatives were successfully synthesized to test for their analgesic activity. Three of them were capsinoids with different acyl chain compared with capsaicin after substitution of ester for amide at C1 position. The other three could be described as capsinoid derivatives with different alkoxy chain, compared with capsaicin after substitution of ester for amide at C1 position and ...