Tetrahedron

An efficient and stereoselective synthesis of (2R, 2′ S)-1-O-(2′-hydroxyhexadecyl) glycerol and its oxo analogs: Potential antitumour compounds from Shark Liver …

…, S Banerjee, C Baskaran, K Bhanu, SP Deshpande…

Index: Baskaran, Subramanian; Baig, Mirza Hamed A.; Banerjee, Sharmila; Baskaran, Chitra; Bhanu, Kanchinadham; Deshpande, Sonali P.; Trivedi, Girish K. Tetrahedron, 1996 , vol. 52, # 18 p. 6437 - 6452

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Citation Number: 17

Abstract

Reproducible, high-yielding, cost efficient, regio-and stereoselective synthesis of the title compound 3 isolated from Shark Liver Oil has been described. The compound 3 is prepared in an overall yield of 41% from chiral synthon 4 by the sequential reaction of 4 with C-13 Wittig salt; hydrogenation; epoxidation and regioselective opening. The oxo analogs 18 and 19 are prepared from four different achiral synthons by the sequential regioselective ...