The [3+ 2] dipolar cycloaddition reactions of the unstabilised azomethine ylide precursor benzyl (methoxymethyl)(trimethylsilylmethyl) amine with 12 electron-deficient alkenes in the presence of catalytic trifluoroacetic acid are examined under continuous flow conditions (20– 100° C, 10–60min residence time). The more reactive and hazardous alkenes such as ethyl acrylate, N-methylmaleimide and (E)-2-nitrostyrene afford substituted N-benzylpyrrolidine ...
