A series of aminomethyl-substituted cyclic imides (11) based on the 2, 5-pyrrolidinedione (X= CHP, succinimide) and 2, 44midazolidinedione (X= NH, hydantoin) ring systems have been prepared. The compounds were designed on the basis of a potential interaction in the y-aminobutyric acid (GABA) neurotransmitter system and evaluated for anticonvulsant activity. The 3-(aminomethyl)-2, 5-pyrrolidinediones were prepared by a dehydration ...
