O 6-(Alkyl/aralkyl) guanosine and 2'-Deoxyguanosine Derivatives: Synthesis and Ability To Enhance Chloroethylnitrosourea Antitumor Action

E Mounetou, E Debiton, C Buchdahl…

Index: Mounetou, Emmanuelle; Debiton, Eric; Buchdahl, Catherine; Gardette, Daniel; Gramain, Jean-Claude; Maurizis, Jean-Claude; Veyre, Annie; Madelmont, Jean-Claude Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2902 - 2909

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Citation Number: 20

Abstract

A series of O 6-(alkyl/aralkyl) guanosines and 2'-deoxyguanosine analogs extended to peracetyl and N 2-acetyl derivatives, potentially water soluble, was synthesized. Each was associated with N'-(2-chloroethyl)-N-[2-(methylsulfonyl) ethyl]-N'-nitrosourea for in vitro evaluation on M4Beu melanoma cells of their ability to enhance the cytotoxic effect of this chloroethylnitrosourea, which is frequently reduced by repairs performed by O 6- ...