An Efficacious Protocol for 4??Substituted 3, 4??Dihydropyrimidinones: Synthesis and Calcium Channel Binding Studies

K Singh, D Arora, D Falkowski, Q Liu…

Index: Singh, Kamaljit; Arora, Divya; Falkowski, Danielle; Liu, Qingxin; Moreland, Robert S. European Journal of Organic Chemistry, 2009 , # 19 p. 3258 - 3264

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Citation Number: 16

Abstract

Abstract Ethyl 1, 2-dihydro-1, 6-dimethyl/6-methyl-2-oxopyrimidine-5-carboxylates react with C-nucleophiles as well as the anion of the enantiopure chiral auxiliary (1R, 2S, 5R)-(–)- methyl (S)-p-toluenesulfinate to afford 4-substituted and enantiopure congeners of medicinally potent Biginelli dihydropyrimidinones. The calcium channel blocking activity of some of the compounds was evaluated and compared with nifedipine for their ability to ...