Substrate profiling and aldehyde dismutase activity of the Kvβ 2 subunit of the mammalian Kv1 potassium channel

K Alka, BJ Ryan, JO Dolly, GTM Henehan

Index: Alka, Kumari; Ryan, Barry J.; Dolly, J. Oliver; Henehan, Gary T.M. International Journal of Biochemistry and Cell Biology, 2010 , vol. 42, # 12 p. 2012 - 2018

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Citation Number: 2

Abstract

Voltage-dependent potassium channels (Kv) are involved in various cellular signalling processes by governing the membrane potential of excitable cells. The cytosolic face of these α subunit-containing channels is associated with β subunits that can modulate channel responses. Surprisingly, the β subunit of the mammalian Kv1 channels, Kvβ2, has a high level of sequence homology with the aldo–keto reductase (AKR) superfamily of ...