Abstract: We have developed an integrated approach for investigating the'bioactive conformations" of the main chain and side chains for the somatostatin analog~[Pro~-Phe~-~- Trp~-Lys~-Thr~~-Phe'~]. A series of analogs have been synthesized incorporating a- methylated and 8-methylated residues at positions 7, 8, and 11. These analogs display dramatic differences in in vitro binding affinities for somatostatin receptors. Using 500-MHz ...
