Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase

DM Nason, SD Heck, MS Bodenstein, JA Lowe…

Index: Nason, Deane M.; Heck, Steven D.; Bodenstein, Mathew S.; Lowe III, John A.; Nelson, Robert B.; Liston, Dane R.; Nolan, Charles E.; Lanyon, Lorraine F.; Ward, Karen M.; Volkmann, Robert A. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4511 - 4514

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Citation Number: 19

Abstract

The synthesis and nNOS and eNOS activity of 6-(4-(dimethylaminoalkyl)-/6-(4- (dimethylaminoalkoxy)-5-ethyl-2-methoxyphenyl)-pyridin-2-ylamines and 6-(4- (dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-2, 5-dimethoxyphenyl)-pyridin-2-ylamines 1–8 are described. These compounds are potent inhibitors of the human nNOS isoform.