Design and Synthesis of (R)??1??Arylsulfonylpiperidine??2??carboxamides as 11β??Hydroxysteroid Dehydrogenase Type 1 Inhibitors

…, H Liu, J Yu, Z Xu, Q Chen, C Ma, P Li, B Xiong…

Index: Xia, Guangxin; Liu, Lin; Liu, Haiyan; Yu, Jianxin; Xu, Zhenmin; Chen, Qian; Ma, Chen; Li, Ping; Xiong, Bing; Liu, Xuejun; Shen, Jingkang ChemMedChem, 2013 , vol. 8, # 4 p. 577 - 581

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Citation Number: 4

Abstract

Metabolic syndrome includes a series of associated metabolic abnormalities such as insulin resistance, type 2 diabetes (T2D), dyslipidemia, hypertension, and visceral obesity.[1] Studies have shown that cortisol levels in liver and adipose tissues of patients with metabolic syndrome tend to be higher than in healthy individuals.[2, 3] There is also strong evidence that the glucocorticoid action relates to metabolic diseases. Glucocorticoid ...