e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Design, synthesis, and properties of (4S)-7-(4-amino-2-substituted-pyrrolidin-1-yl) quinolone-3-carboxylic acids

T Rosen, DTW Chu, IM Lico…

Index: Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1598 - 1611

Full Text: HTML

Citation Number: 81

Abstract

... 1986, 21, 139 and references therein. (3) Cozzarelli, NR Science (Washington, DC) 1980, 207, 953. D 1988 American Chemical Society Page 2. Quinolonecarboxylic Acids ... Ho \ HO\ + = (J' (type A) NHz N Hz Journal of Medicinal Chemistry, 1988, Vol. 31, No. 8 1599 ...

(2S,4R)-tert-butyl-4-(tert-butyldimethylsilyloxy)-2-((methylsulfonyloxy)methyl)pyrrolidine-1-carboxylate Structure

(2S,4R)-tert-bu...

~%

(2R,4R)-(+)-AZETIDINE-2,4-DICARBOXYLICACID Structure

(2R,4R)-(+)-AZE...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

(2R,4R)-(+)-AZETIDINE-2,4-DICARBOXYLICACID Structure

(2R,4R)-(+)-AZE...

(2S,4R)-1-Boc-2-methylcarboxylate-4-tert-butyldimethylsilyloxy-pyrrolidine Structure

(2S,4R)-1-Boc-2...

~%

(2R,4R)-(+)-AZETIDINE-2,4-DICARBOXYLICACID Structure

(2R,4R)-(+)-AZE...

(2S,4R)-METHYL 4-HYDROXYPYRROLIDINE-2-CARBOXYLATE Structure

(2S,4R)-METHYL ...

~%

(2R,4R)-(+)-AZETIDINE-2,4-DICARBOXYLICACID Structure

(2R,4R)-(+)-AZE...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

(2R,4R)-n-Boc-2-(Fluoromethyl)-4-hydroxypyrrolidine Structure

(2R,4R)-n-Boc-2...

N-Boc-cis-4-hydroxy-D-proline methyl ester Structure

N-Boc-cis-4-hyd...

~%

(2R,4R)-n-Boc-2-(Fluoromethyl)-4-hydroxypyrrolidine Structure

(2R,4R)-n-Boc-2...

D-Proline, 4-hydroxy-, methyl ester hydrochloride Structure

D-Proline, 4-hy...

~%

(2R,4R)-n-Boc-2-(Fluoromethyl)-4-hydroxypyrrolidine Structure

(2R,4R)-n-Boc-2...

N-α-tert-butyloxycarbonyl-cis-4-(2-tetrahydropyranyloxy)-D-prolinol Structure

N-α-tert-butylo...

~%

(2R,4R)-n-Boc-2-(Fluoromethyl)-4-hydroxypyrrolidine Structure

(2R,4R)-n-Boc-2...

(2R,4R)-tert-butyl 2-(((methylsulfonyl)oxy)methyl)-4-((tetrahydro-2H-pyran-2-yl)oxy)pyrrolidine-1-carboxylate Structure

(2R,4R)-tert-bu...

~%

(2R,4R)-n-Boc-2-(Fluoromethyl)-4-hydroxypyrrolidine Structure

(2R,4R)-n-Boc-2...

cis-4-Hydroxyproline Structure

cis-4-Hydroxyproline

~%

(2R,4R)-n-Boc-2-(Fluoromethyl)-4-hydroxypyrrolidine Structure

(2R,4R)-n-Boc-2...

Direct Asymmetric a nti-Mannich-Type Reactions Catalyzed by ...

[Journal of the American Chemical Society, , vol. 128, # 4 p. 1040 - 1041]