Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases

…, J Park, CY Leung, P Gormley…

Index: Waszkuc, Wieslaw; Janecki, Tomasz; Bodalski, Ryszard Synthesis, 1984 , # 12 p. 1025 - 1027

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Citation Number: 9

Abstract

... Inhibitors Used for Screening: N-BPs and ThP-BPs with General Structure 5 and 6, Respectively (The Synthesis of These Compounds Were Previously Reported(12)). ... 6a (act) complex (PDB ID 4JVJ; Figure 5a).(12d) In the hFPPS/6a (allo) complex, the p-tolyl substituent ...