Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators

…, GF Allan, T Sbriscia, O Linton, SG Lundeen…

Index: Zhang, Xuqing; Li, Xiaojie; Allan, George F.; Sbriscia, Tifanie; Linton, Olivia; Lundeen, Scott G.; Sui, Zhihua Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 439 - 443

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Citation Number: 16

Abstract

... Bioorganic & Medicinal Chemistry Letters. Volume 17, Issue 2, 15 January 2007, Pages 439–443. ... Any modification on R 1 , R 2 , R 3 , R 4 , and R 5 seemed to be detrimental to the activity and led to inactive compounds, as exemplified by 10a–b, 10e–g, and 10i–k in Table 1. Compound 10h with trifluoro acetyl substitution on R 6 was an exception that maintained agonistic activity on levator ani muscle and prostate. ... 10f, CN, CF 3, H, Me, per-F–Ph, H, 21, <10, <10. ...