Organic letters

Tandem Sonogashira coupling: An efficient tool for the synthesis of diarylalkynes

Z Novák, P Nemes, A Kotschy

Index: Novak, Zoltan; Nemes, Peter; Kotschy, Andras Organic Letters, 2004 , vol. 6, # 26 p. 4917 - 4920

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Citation Number: 99

Abstract

The tandem Sonogashira coupling reaction of aryl halides provides an efficient method for the synthesis of diarylalkynes. Several aryl halides were coupled with 2-methyl-3-butyn-2-ol as acetylene source in the presence of PdCl2 (PPh3) 2 and CuI. Following the deprotection of the acetylene moiety in the same pot using a strong base, the Sonogashira coupling of a second aryl halide led to the formation of the appropriate diarylakyne. The established ...