Two convenient methods for the synthesis of chiral 2-ethynylaziridines from natural α-amino acids are described. Sodium hydride-promoted aziridination of mesylates of 4- arylsulfonylamino-2-bromoalk-2-en-1-ols yields trans-2-(1-bromovinyl) aziridines in a highly stereoselective manner, and subsequent dehydrobromination of the aziridines by potassium tert-butoxide gives separable stereoisomeric mixtures of trans-and cis-2-ethynylaziridines ...
![(3R,4S)-4-[N-(tert-Butoxycarbonyl)amino]-5-methyl-1-trimethylsilylhex-1-yn-3-ol Structure](https://image.chemsrc.com/caspic/409/253676-10-7.png)
