Analogs of 1, 3-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated for their antileishmanial activity. Of the many active compounds, 1-(3-N, N-bis methoxycarbonyl guanidino) propyl-4-methylpiperidine piperazine (4ef) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration.
