Tetrahedron

Phosphorylation of nucleoside derivatives with aryl phosphoramidochloridates

JH Van Boom, PMJ Burgers, R Crea, W Luyten…

Index: Van Boom,J.H. et al. Tetrahedron, 1975 , vol. 31, p. 2953 - 2959

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Citation Number: 26

Abstract

The preparation of three aryl phosphorocyclohexylamidochloridates (7a, 7b and 7c) and an aryl phosphoromorpholidochloridate (8) is described. These aryl phosphoramidochloridates react with 2′, 3′-O-methoxymethylene-uridine,-4-N-anisoylcytidine and-6-N- anisoyladenosine (9a, 9b and 9c, respectively), in the presence of the 1-ethylimidazole derivative (11a) to give high yields of the corresponding fully-protected 5′- ...