1, 2, 3, 4-Tetrahydroisoquinoline-1-carbonitriles can serve as starting materials for the one- pot synthesis of 5, 6-dihydropyrrolo [2, 1 a] isoquinolines and 1-benzyl-3, 4- dihydroisoquinolines. The latter compounds were transformed to lamellarin G trimethyl ether and lamellarin U in short reaction sequences. This method allows the introduction of acid- sensitive protecting groups for the phenolic hydroxy functions which would be cleaved ...
