Tetracyclic spirooxindole blockers of hNaV1. 7: activity in vitro and in CFA-induced inflammatory pain model

…, S Liu, JA Cadieux, T Hsieh, M Chafeev, S Sun…

Index: Chowdhury, Sultan; Liu, Shifeng; Cadieux, Jay A.; Hsieh, Tom; Chafeev, Mikhail; Sun, Shaoyi; Jia, Qi; Sun, Jianyu; Wood, Mark; Langille, Jonathan; Sviridov, Serguei; Fu, Jianmin; Zhang, Zaihui; Chui, Ray; Wang, Audrey; Cheng, Xing; Zhong, Jing; Hossain, Sazzad; Khakh, Kuldip; Rajlic, Ivana; Verschoof, Henry; Kwan, Rainbow; Young, Wendy Medicinal Chemistry Research, 2013 , vol. 22, # 4 p. 1825 - 1836

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Citation Number: 9

Abstract

... First online: 12 August 2012. Tetracyclic spirooxindole blockers of hNa V 1.7: activity in vitro and in CFA-induced inflammatory pain model. Sultan ChowdhuryAffiliated withDepartment of Medicinal Chemistry, Xenon Pharmaceuticals Inc. Email author; , Shifeng LiuAffiliated withDepartment of Medicinal Chemistry, Xenon Pharmaceuticals Inc. , Jay A. CadieuxAffiliated withDepartment of Medicinal Chemistry, Xenon Pharmaceuticals Inc. ...

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3-Pyridinols and 5-pyrimidinols: Tailor-made for use in syne...

[Valgimigli, Luca; Bartolomei, Daniele; Amorati, Riccardo; Haidasz, Evan; Hanthorn, Jason J.; Nara, Susheel J.; Brinkhorst, Johan; Pratt, Derek A. Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 2781 - 2792]

Structure-activity studies related to ABT-594, a potent nono...

[Holladay, Mark W.; Bai, Hao; Li, Yihong; Lin, Nan-Horng; Daanen, Jerome F.; Ryther, Keith B.; Wasicak, James T.; Kincaid, John F.; He, Yun; Hettinger, Anne-Marie; Huang, Peggy; Anderson, David J.; Bannon, Anthony W.; Buckley, Michael J.; Campbell, Jeffrey E.; Donnelly-Roberts, Diana L.; Gunther, Karen L.; Kim, David J. B.; Kuntzweiler, Theresa A.; Sullivan, James P.; Decker, Michael W.; Arneric, Stephen P. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 19 p. 2797 - 2802]