Chemical tagging of a drug target using 5-sulfonyl tetrazole

…, H Takabatake, K Nakajima, Y Takasu, T Yagura…

Index: Otsuki, Satsuki; Nishimura, Shinichi; Takabatake, Hisae; Nakajima, Kozue; Takasu, Yasuaki; Yagura, Toru; Sakai, Yuki; Hattori, Akira; Kakeya, Hideaki Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1608 - 1611

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Citation Number: 9

Abstract

Irreversible modification is one of the most promising strategies to identify cellular receptors of bioactive small molecules. Here we report that receptor proteins can be chemically tagged using a 5-sulfonyl tetrazole probe. 5-Sulfonyl tetrazole easily accepted nucleophilic attack of thiol groups, while 5-sulfinyl tetrazole did not. These functional groups were introduced into probe molecules of a natural product. Cyclosporine A, an immunosuppressant produced ...