Biological activity of analogues of YM022. Novel (3-amino substituted phenyl) urea derivatives of 1, 4-benzodiazepin-2-one as gastrin/cholecystokinin-B receptor …

…, A NISHIDA, S AKUZAWA, K MIYATA, T MASE…

Index: Satoh, Masato; Okamoto, Yoshinori; Koshio, Hiroyuki; Ohta, Mitsuaki; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji; Mase, Toshiyasu; Semple, Graeme Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 7 p. 1412 - 1414

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Citation Number: 9

Abstract

A series of (3-substituted phenyl) urea analogues of the potent gastrin/cholecystokinin (CCK)-B receptor antagonist YM022 has been prepared. Structure-activity relationship studies of this series suggested that a number of analogues retained good in vitro potency for gastrin/CCK-B receptor. In particular, the (3-amino substituted phenyl) urea derivatives (10-12) were more potent inhibitors of pentagastrin-induced gastric acid secretion in rats ...

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