The enzymatic reduction of 2-methyl-2-(trideuteriomethyl) cyclohexane-1, 3-dione with Kloeckera magna is not stereospecific with respect to the a center. The reaction product, 2- methyl-2-(trideuteriomethyl)-3-hydroxycyclohexanone, was shown to possess the 3s configuration. The circular dichroism and X-ray crystallographic data lead to the unexpected conclusion that the reduction product assumes the conformation with an axially oriented ...
[Laverde Jr., Antonio; Da Conceicao, Gelson J. A.; Queiroz, Sonia C. N.; Fujiwara, Fred Y.; Marsaioli, Anita J. Magnetic Resonance in Chemistry, 2002 , vol. 40, # 7 p. 433 - 442]
