A wealth of studies have established the crucial role of angiotensin-converting enzyme (ACE, peptidyldipeptide hydrolase, EC 3.4. 15.1) in human hypertension of renovascular origin. Furthermore, the ACE activity in vitro indicates its involvement in metabolism of other biologically active peptides.'Inhibitors of this zinc metalloprotease have been successfully used as antihypertensive agents, which exert their effect by inhibiting the formation of the ...
