Aerobic Alcohol Oxidation Coupled to Palladium??Catalyzed Alkene Hydroarylation with Boronic Esters

Y Iwai, KM Gligorich, MS Sigman

Index: Iwai, Yasumasa; Gligorich, Keith M.; Sigman, Matthew S. Angewandte Chemie - International Edition, 2008 , vol. 47, # 17 p. 3219 - 3222

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Citation Number: 55

Abstract

The Suzuki reaction, which couples an organohalide and an organoboron compound,[1] is an attractive cross-coupling reaction for use in the synthesis of natural products [2] and pharmaceuticals.[3] This utility is mainly because of the excellent functional group compatibility, ease of preparation of boronic acid derivatives, and the low toxicity of the boron byproducts.[2] The mechanistic details have been widely investigated and the ...