Synthesis of new derivatives of 4??amino??2, 4??dihydro??1, 2, 4??triazol??3??one as potential antibacterial agents

F Malbec, R Milcent, P Vicart…

Index: Malbec; Milcent; Vicart; Bure Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 6 p. 1769 - 1774

Full Text: HTML

Citation Number: 76

Abstract

Abstract Thirty new 2-substituted-4-amino-5-alkyl or aryl-2, 4-dihydro-1, 2, 4-triazol-3-ones and ten 2-substituted-5-alkyl or aryl-4-(5-nitro-2-furfurylidene) amino-2, 4-dihydro-1, 2, 4- triazol-3-ones were synthesized and characterised by their sharp melting points, elemental analysis, ir and 1 H nmr spectra. These new derivatives of 5-nitro-2-furaldehyde were screened for their antibacterial activities. Most of the compounds showed good activity ...