Fluorine transfer to alkyl radicals

M Rueda-Becerril, C Chatalova Sazepin…

Index: Rueda-Becerril, Montserrat; Chatalova Sazepin, Claire; Leung, Joe C. T.; Okbinoglu, Tulin; Kennepohl, Pierre; Paquin, Jean-Francois; Sammis, Glenn M. Journal of the American Chemical Society, 2012 , vol. 134, # 9 p. 4026 - 4029

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Citation Number: 113

Abstract

The development of new synthetic technologies for the selective fluorination of organic compounds has increased with the escalating importance of fluorine-containing pharmaceuticals. Traditional methods potentially applicable to drug synthesis rely on the use of ionic forms of fluorine (F–or F+). Radical methods, while potentially attractive as a complementary approach, are hindered by a paucity of safe sources of atomic fluorine (F•) ...