The regioselectivity of the protonation is an attractive and intricate problem underpinning the fascinating chemistry of enamines [1]. Understanding the relationships between structure and protonation site preference of enamine is a key-issue since their reactivity is directly related to their basicity [2] and [3]. In general, enamines are ambident conjugated systems in which the N- or C β -atom of the enamine moiety as well as (in some cases) the heteroatom of the ...
