Conversion of aldoximes into nitriles with Raney nickel in refluxing 2-propanol

DR Zuidema, AL Dennison, EY Park…

Index: Zuidema, Daniel R.; Dennison, Ami L.; Park, Elizabeth Y.; Mebane, Robert C. Synthetic Communications, 2008 , vol. 38, # 21 p. 3810 - 3815

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Citation Number: 15

Abstract

Aldoximes are readily dehydrated to nitriles with Raney nickel in refluxing 2-propanol. ... Aldoximes are readily dehydrated to nitriles with Raney nickel in refluxing 2-propanol. ... Raney nickel is a well-known heterogeneous catalyst for effecting functional group transformations, particularly hydrogenation reactions. [ 1-3 View all references ] We and others have employed Raney nickel in catalytic transfer hydrogenations (CTH) using 2-propanol as a hydrogen donor to ...