Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4 (3H)-quinazolinones

…, MC Sleevi, JA Campbell, TD Greenwood

Index: Wolfe, James F.; Rathman, Terry L.; Sleevi, Mark C.; Campbell, James A.; Greenwood, Thomas D. Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 161 - 166

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Citation Number: 260

Abstract

A series of 4 (3H)-quinazolinones structurally related to 2-methyl-3-o-tolyl-4 (3H)- quinazolinone (methaqualone, 3) were synthesized and evaluated for anticonvulsant activity. Preliminary screening of these compounds revealed that 2-[2-oxo-2-(4-pyridyl) ethyl]- 3-aryl-4 (3H)-quinazolinones 61 and 8i, 8k, and 8p-r having a single ortho substituent on the 3-aryl group had the most promising anticonvulsant activity. Compounds 61 and 8i ...