e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Ionic liquids on demand in continuous flow
D Wilms, J Klos, AFM Kilbinger…
Index: Wilms, Daniel; Klos, Johannes; Kilbinger, Andreas F. M.; Loewe, Holger; Frey, Holger Organic Process Research and Development, 2009 , vol. 13, # 5 p. 961 - 964
We report on the development of an alternative protocol for the facile, solvent-free synthesis of various novel imidazolium-based ionic liquids (ILs) that affords highly pure products without the necessity of subsequent purification steps. The continuous approach is based on the combination of HPLC pumps with a micromixer and a capillary residence tube. Our system provides a high degree of control over the alkylation reactions due to a high ...