Journal of medicinal chemistry

Synthesis and cardiovascular activity of a new series of cyclohexylaralkylamine derivatives related to perhexiline

G Leclerc, N Decker, J Schwartz

Index: Leclerc, Gerard; Decker, Nicole; Schwartz, Jean Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 709 - 714

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Citation Number: 8

Abstract

A series of 24 cyclohexylaralkylamine derivatives related to perhexiline has been synthesized and screened for cardiovascular activity. All the compounds contained an exocyclic amine which was substituted either by an alkyl, cycloalkyl, or aralkyl group. In the hope of further reducing toxicity, the synthesis of p-tolyl-and p-hydroxyphenyl derivatives 23 and 24 was undertaken. The effect of separating the cyclohexylamine moiety with respect ...