Cardiotonic agents. 5. 1, 2-Dihydro-5-[4-(1H-imidazol-1-yl) phenyl]-6-methyl-2-oxo-3-pyridinecarbonitriles and related compounds. Synthesis and inotropic activity

I Sircar, BL Duell, JA Bristol, RE Weishaar…

Index: Sircar; Duell; Bristol; Weishaar; Evans Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1023 - 1029

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Citation Number: 29

Abstract

" Literat~ re'~ reports mp 149-150 OC.* Yields were not optim-The analyses were within 0.4% of the calculated value. Compounds were purified by chromatography over silica gel using Compound le was available from ized. dichloromethane as eluant. Aldrich Chemical Co. era1 procedure of Sitkina et al. 12 Treatment of la-g with nitroethane in ethanol in the presence of a catalytic amount of &alanine gave the corresponding nitrostyrenes 2a-g ( ...