e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: Preparation of 3-aryl-2-pyridone analogues generated by solution-and solid-phase parallel …
…, J Georgsson, MJ Johansson, Å Rosenquist…
Index: Semple, Graeme; Andersson, Britt-Marie; Chhajlani, Vijay; Georgsson, Jennie; Johansson, Magnus J.; Rosenquist, Asa; Swanson, Lars Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1141 - 1145
New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution-and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported.
