e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
The Journal of organic chemistry
Enantioselective synthesis of the optically active α-methylene-β-hydroxy esters, equivalent compounds to morita-baylis-hillman adducts, using successive asymmetric …
The asymmetric aldol reaction of a tetra-substituted ketene silyl acetal including an alkylseleno group with aldehydes has been developed by the promotion of Sn (OTf) 2 coordinated with a chiral diamine to afford the corresponding aldols having chiral quaternary centers at the α-positions. The facile oxidative deselenization of these aldol compounds produces optically active α-methylene-β-hydroxy esters which correspond to adducts ...
