Tetrahedron letters

Synthesis of 9-(3-hydroxypropoxy) guanine, a novel antiviral acyclonucleoside

MR Harnden, A Parkin, PG Wyatt

Index: Harnden, M. R.; Parkin, A.; Wyatt, P. G. Tetrahedron Letters, 1988 ,  vol. 29,  # 6  p. 701 - 704

Full Text: HTML

Citation Number: 26

Abstract

ABSTRACT: Synthetic approaches to 9-(3-hydroxypropoxy) guanine (2) involving the intermediacy of either a 1-alkoxyimidazole (1) or a 4-alkoxyaminopyrimidine (13) are described. This 9-alkoxyguanine (L) has potent and selective anti-herpesvirus activityand is the first reported member of a new series of antiviral acyclonucleosides.