Synthesis of 25-hydroxy-and 1. alpha., 25-dihydroxy vitamin D3 from vitamin D2 (calciferol)

DR Andrews, DHR Barton, RH Hesse…

Index: Andrews; Barton; Hesse; Pechet Journal of Organic Chemistry, 1986 ,  vol. 51,  # 25  p. 4819 - 4828

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Citation Number: 79

Abstract

4: R'= H, R2= OH essential for enzymatic hydroxylation to la, 25-dihydroxyvitamin D,(3), which is thought to be the hormonal form of the vitamin. The introduction of the la-hydroxy substituent is an essential metabolic event for the action of vitamin D on b0ne. l la, 25- Dihydroxyvitamin D3 (3), together with the synthetic analogue la-hydroxyvitamin D3 (4), has been studied clinically in several disease states such as chronic renal failure, ...

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