Enantiospecific total synthesis of the sesquiterpene antibiotics (-)-punctatin A and (+)-punctatin D

T Sugimura, LA Paquette

Index: Sugimura; Paquette Journal of the American Chemical Society, 1987 ,  vol. 109,  # 10  p. 3017 - 3024

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Citation Number: 84

Abstract

Abstract: Total syntheses of the levorotatory enantiomer of punctatin A (antibiotic M95464) and the dextrorotatory enantiomer of punctatin D (antibiotic M167906) have been achieved. The identities of the synthetic materials with the corresponding natural products, which were confirmed spectroscopically and by [a] D, permitted the assignment of absolute configuration. These structurally novel trans fused tertiary cyclobutyl alcohol antibiotics ...