Preparation and biological activity of tricyclic non-steroidal inhibitors of human steroid 5α-reductase

AD Abell, MA Levy, DA Holt

Index: Abell, Andrew D.; Brandt, Martin; Levy, Mark A.; Holt, Dennis A. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 11 p. 1663 - 1667

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Citation Number: 12

Abstract

The synthesis and in vitro inhibitory studies against human types 1 and 2 steroid 5α- reductase of a series of 9, 10-dihydrophenanthrene-2-carboxylic acids is reported. A (4- carboxy) phenyl substituent at C-7 provides a compound with activity against both isozymes. The structural features responsible for activity are discussed.